These data were derived from Gene Expression Omnibus data set GSE30219. “An unexplored consequence of epigenetic alterations associated with cancer is the ectopic expression of tissue-restricted genes. Here, a new strategy was developed to decipher genome-wide expression data in search for these “off-context” gene activations, which consisted first, in identifying a large number of tissue-specific genes normally epigenetically silenced in most somatic cells and second, in using them as cancer biomarkers on an “on/off” basis.”
Comment(s): This data set was curated as part of the Biomarker Benchmark project. The expression data were normalized using the SCAN algorithm and summarized at the gene level using Ensembl identifiers.
Data Source(s): https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE30219
Citation(s): PubMed article