These data were derived from Gene Expression Omnibus data set GSE5462. “In the present investigation, we have exploited the opportunity provided by neoadjuvant treatment of a group of postmenopausal women with large operable or locally advanced breast cancer (in which therapy is given with the primary tumour remaining within the breast) to take sequential biopsies of the same cancers before and after 10-14 days treatment with letrozole. RNA extracted from the biopsies has been subjected to Affymetrix microarray analysis and the data from paired biopsies interrogated to discover genes whose expression is most influenced by oestrogen deprivation.”
Comment(s): This data set was curated as part of the Biomarker Benchmark project. The expression data were normalized using the SCAN algorithm and summarized at the gene level using Ensembl identifiers.
Data Source(s): https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE5462
Citation(s):